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In 6 extra placebo-controlled scientific tests (3 in severe mania as well as 3 in schizophrenia) utilizing changeable dosages of Seroquel, there were no distinctions between the Seroquel and placebo therapy teams in the occurrence of EPS, as examined by Simpson-Angus overall ratings, spontaneous issues of EPS as well as using concomitant anticholinergic medications to deal with EPS.

In 2 placebo-controlled medical tests for the therapy of bipolar depression using 300 milligrams and also 600 mg of Seroquel, the occurrence of damaging reactions potentially pertaining to EPS was 12 % in both dose teams and also 6 % in the placebo group. In these researches, the incidence of the specific unfavorable responses (akathisia, extrapyramidal disorder, tremor, dyskinesia, dystonia, uneasyness, contraction uncontrolled, psychomotor hyperactivity as well as muscular tissue rigidness) were normally low and also did not go beyond 4 % in any kind of therapy group.

The 3 therapy teams were comparable in mean modification in SAS overall rating as well as BARS Global Assessment rating at the end of treatment. Using concomitant anticholinergic medicines was comparable as well as occasional across the 3 treatment teams.

The details listed below is obtained from a scientific test database for Seroquel including over 1000 pediatric clients. This database consists of 677 people subjected to Seroquel for the therapy of schizophrenia and 393 children and adolescents (10-17 years aged) exposed to Seroquel for the therapy of severe bipolar mania.

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